Agent nonsedating antihistamine

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Chlorpheniramine maleate, although referenced to the BNF guidance regarding breast feeding and pregnancy below, is not explicitly mentioned in any of the BNF guidance and can be used with caution in these circumstances.

During pregnancy: The information provided herein should not be used for diagnosis or treatment of any medical condition.

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This distinction between generations must be taken with caution because a product considered as non sedative or not antimuscarinic can, in certain circumstances, large doses or particular susceptibility of the patient ,have these effects.

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They have a longer duration of action and longer plasma half-life than the first generationdrugs, which makes it possible to reduce the number of daily intakes.

They do not have, in normal dose, antimuscarinic effect, except mequitazine which has a mild antimuscarinic effect.

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